Genomac Innovative Multi-omics Research on Infectious Diseases in Nigeria (GIMRID)
Comprehensive Multi-Omics Research on Vibrio cholerae in Nigeria.
Integrating Functional Genomics of Infectious Disease, Comparative Genomics, Variant Analysis, and Novel Therapeutic Peptide R&D.
75000+
Trained Bioinformaticians and Practicing Professionals Globally.
120+
Countries Impacted: Making a Difference Worldwide.
1000+
Research publications, Scholarships, Grants, and Jobs by our Participations.
About the Research Initiative (PHASE 1.0)
The research initiative (PHASE 1.0) aims to conduct a comprehensive multi-omics study on the new strain of Vibrio cholerae in Nigeria, starting with sample collection from multiple sites across the country. Following DNA sequencing, the research will transition to an in silico phase, integrating functional genomics of infectious diseases, comparative genomics, variant analysis, and novel peptide therapeutic R&D.
By investigating the outbreak dynamics, spread, resistance mechanisms, and genetic variations of the new strain, the research aims to enhance understanding of its pathogenicity and transmission patterns. This will involve whole genome sequencing and the analysis of virulence factors, mobile genetic elements, and antimicrobial resistance genes. Additionally, the study will explore the comparative genomics of different strains, including functional analysis, subsystem categorization, whole genome alignment, pan/core genomics, DNA-DNA hybridization, MLST and ANI and phylogenomic analysis. Through variant analysis, researchers will examine variations in mobile genetic elements, antimicrobial resistance, and virulence factors.
The insights gained from these analyses will inform the therapeutic research and development phase, which focuses on identifying and optimizing novel peptide candidates that can effectively target and neutralize the bacteria. This will involve in silico analysis, peptide docking, molecular docking, and preclinical testing to assess the safety and efficacy of the peptides. The ultimate goal is to develop a novel anti-bacterial therapeutic drug based on these peptides, which will be subject to clinical trials before becoming available for widespread use. This research initiative holds the potential to significantly contribute to the control and prevention of cholera outbreaks in Nigeria and beyond.
DURATION: 12 MONTHS
STARTING DATE: JANUARY, 2025
AGENDA: weekly meeting ...
RESEARCH FEATURES
Explore Multi-Omics Sciences
Explore the diverse fields of omics sciences, and transform your findings into publishable papers.
Personalized Mentorship
Each participant is assigned a dedicated mentor virtually, receives guidance, feedback, and participates in Q&A sessions for in-depth understanding.
Flexible Duration
Explore content at your own pace, access recorded tutorials for flexible learning, and accommodate different time zones for collaborative activities.
Hands-on Practical Training Sessions
Engage in guided exploration of video tutorials for tool usage, and apply knowledge through real-life projects.
Tailored Real-life Research Projects
Design and pursue individual or group projects tailored to specific fields of interest, using real-life datasets, get accurate results, and potential publication.
Community Engagement
Interact with peers, collaborate on projects, share discoveries within the community, and explore networking opportunities.
Skills and Expertise Development
Gain in-demand skills in omics research, collaborate within the community, and unlock the potential of data.
Publication and Expert Support
Receive guidance on manuscript preparation, navigate the peer-review process, and get support in converting projects into publishable research.
Certificate of Research Excellence & Recommendation Letter
Obtain a recognized certificate of research excellence and recommendation letter.
SKILLS YOU WILL GAIN: Basics to Advance
THE MAIN RESEARCH AREAS
WET LAB
Sample Collection From Multiple sites Across Nigeria
The aim is to collect and process samples from cholera outbreak sites across diverse Nigerian regions. Environmental (water, soil), Food, and clinical (stool, vomit) samples will be gathered.
Isolation and Characterization of Vibrio cholerae Strains
To isolate and characterize resistant Vibrio cholerae strains. This involves culturing samples on selective media, confirming V. cholerae presence through biochemical tests, sensitivity assays, and serotyping
Whole Genome Sequencing of Vibrio cholerae Strains
To apply molecular biology techniques, including DNA extraction and whole genome sequencing (WGS), to analyze Vibrio cholerae strains using either Illumina or PacBio platforms.
DRY LAB (Insilico Multi-omics Approach)
The Insilico Multi-omics Approach refers to the usage of computational methods and tools to combine and examine data from several "omics" layers—genomics, transcriptomics, proteomics, metabolomics, and epigenomics. the Insilico Multi-omics approach will be conducted in this research so that the molecular mechanisms driving the disease can be revealed and identify potential biomarkers for diagnosis or treatment. Alongside identifying new drug targets while understanding complex biological data.
Genomics of Infectious Diseases
To conduct a comprehensive genomic analysis of multi-drug resistant bacteria, focusing on data acquisition, functional annotation, resistome and virulome profiling, variant annotation, geo-mapping, and identification of virulence factors to understand mechanisms of drug resistance, pathogenicity, and transmission routes.
Comparative Genomics Analysis
To perform comparative genomics on Vibrio cholerae strains, focusing on annotation, subsystem categorization, phylogenomic analysis, core/pan-genomics, ANI, DNA-DNA hybridization, whole genome alignment, MLST, and horizontal gene transfer to identify key genetic traits related to pathogenicity, resistance, and evolution.
Genetic Variation Study in Vibrio cholerae
To conduct a detailed variant study on Vibrio cholerae strains, identifying SNPs, indels, structural variants, and AMR gene variations through variant calling and whole genome variation analysis. Including MGE to understand their role in spreading resistance and virulence, and assessing the functional impact of detected variants on protein structure and resistance profiles.
Translational Machine Learning-Therapeutic R&D
To integrate machine learning and multi-omics data to identify and optimize anti-cholera peptide candidates, focusing on peptide efficacy, docking simulations, molecular docking, and resistance prediction through evolutionary modeling and combination therapy exploration.
Download the full research proposal to explore our comprehensive study objectives, methodology, and anticipated outcomes, designed to advance knowledge and innovation in this field.
TOTAL RESEARCH BUDGET
Basics to Advanced Level of Expertise
TOTAL BUDGET: #114,034,602
GENOMAC HOLDINGS is Covering: #100,000,000 for 50 Members
APPLICATION
Research Commitment Fee: #300,000
RESEARCH FELLOW
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Research Involvement: Involvement in 2 Research Areas of choice, allowing for deeper engagement and exposure to various facets of the project.
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Co-Authorship: Participation and co-authorship in 2 research papers.
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Skills Training: Comprehensive training in data analysis, research writing, and competence in genomics and bioinformatics.
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Capacity Building: In-depth capacity-building sessions focused on project management, advanced bioinformatics analysis, and multi-omics research techniques.
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In Silico Bioinformatics Analysis: Training and hands-on practice in bioinformatics analysis with advanced tools, covered by Genomac Institute, worth ₦2,000,000.
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Software Access: Free access to advanced bioinformatics software tools (worth #2,000,000).
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Omics Board Access: Free access to Omics Board for data analysis, team collaboration, and project tracking (worth #2,000,000).
Total Benefits Value: Approximately #6,000,000 + co-authorship, capacity-building experience, and access to exclusive tools.
Research Commitment Fee: #250,000
RESEARCH SCHOLAR
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Research Involvement: Involvement in 1 Research Area of choice, allowing for deeper engagement and exposure to various facets of the project.
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Co-Authorship: Participation and co-authorship in 1 research paper.
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Skills Training: Comprehensive training in data analysis, research writing, and competence in genomics and bioinformatics.
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Capacity Building: In-depth capacity-building sessions focused on project management, advanced bioinformatics analysis, and multi-omics research techniques.
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In Silico Bioinformatics Analysis: Training and hands-on practice in bioinformatics analysis with advanced tools, covered by Genomac Institute, worth ₦1,500,000.
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Software Access: Free access to advanced bioinformatics software tools (worth #1,500,000).
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Omics Board Access: Free access to Omics Board for data analysis, team collaboration, and project tracking (worth #1,500,000).
Total Benefits Value: Approximately #4,500,000 + co-authorship, capacity-building experience, and access to exclusive tools.
other Resources and Access
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Free Lifetime Access: Participants will receive free lifetime access to premier bioinformatics software tools, including GENEIOUS SOFTWARE (valued at $5000).
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Comprehensive Library: Access to a curated selection of books and e-books worth $5,000, covering essential topics in genomics and bioinformatics.
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Essential Tools and Resources: Participants will have access to vital tools, datasets, and resources tailored to their research projects.
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Customized Research Projects: Research projects are tailored based on the comprehensive resources and support available, ensuring an enriching and customized experience.
Requirements
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Passion for Discovery: A deep curiosity about the mysteries of life and a desire to unlock the secrets encoded in genomes.
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Innovative Thinking: An imaginative mindset eager to explore new frontiers and develop novel solutions.
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Collaborative Spirit: Enthusiasm for working with diverse minds globally, sharing insights, and fostering mutual growth.
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Resilience: Determination to overcome challenges and persist in the face of adversity.
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Global Vision: Commitment to contributing to global scientific advancement and addressing universal challenges through research.
GET CERTIFIED
Upon fulfilling program requirements, your certificate from Genomac Institute Inc. will include your name and the CEO's signature, affirming your achievements. With Genomac Institute Inc. now incorporated in the USA, your certification gains added global recognition, enhancing your professional credibility. Outstanding achievers may also receive a Certificate of Excellence and a personalized Letter of Recommendation.
TESTIMONIALS
Hear from some of our Virtual Interns
Dr. Maryam Idrees Malik
Before starting the program, I was a bit apprehensive, as I had previously been taken advantage of by some online scam. But now, I consider myself fortunate that I had stumbled upon this organisation. Kudos team genomac hub! I honour your intentions to create a global impact by helping researchers. Looking forward to learning and growth & thank you for sharing the lifetime activation key of geneious software.
Dr. Noman Sohail
During my time with Genomac Hub, I was offered online classes, clear guidance, and a structured map to proceed with the work, outlining the amazing results. The negotiations were satisfactory overall. I must rate the service 8/10
Blessing O
Attending Genomac Hub workshop helped me navigate the fundamentals of Bioinformatics. It provides a solid foundation for me to move on in my career. The CEO, Oluwaseyi, is very knowledgeable about the course. He is adept at keeping the class engaged and making everyone understand. I recommend Genomac Hub courses and workshops to anyone in any part of the globe.
Nikita Singh
Interesting, understandable, keeps the target audience engaged till the end. The concepts and protocols are explained in a lucid way.